Association between cartilage biomarker level and functional outcome in knee osteoarthritis patients receiving dextrose prolotherapy: a cross-sectional study

Background: Knee osteoarthritis (KOA) is a degenerative joint disease with relatively high prevalence globally and one of the leading causes disability in elderly population. Dextrose prolotherapy (DPT) has been proven effective improving functional outcomes knee osteoarthritis. The effect hypertonic dextrose on cartilage biomarkers not evaluated. Purpose: To evaluate association between biomarker changes clinical among patients KOA who received (DPT). Patients methods: This study was conducted cross-sectional design. Twenty-six participants DPT at weeks 1, 5, 9. Our primary measures were urinary c-terminal telopeptides type II collagen (uCTX-II), measured by an enzyme-linked immunosorbent assay (ELISA), WOMAC score, baseline week 12. Results: There significant improvements all subscales uCTX-II levels after DPT. no correlation score as outcome indicator (p > 0.05), but there are positive correlations pain, functional, total uCTX-II. Conclusion: may reduce degradation improve osteoarthritic knees. Significant drops can affect outcomes, especially scores.